Mental Health
Psychopharmacology / Physical Treatments in Psychiatry
Table of Contents
Psychopharmacology / Physical Treatments in Psychiatry
Physical (Biomedical) Treatments
Biomedical treatments in psychiatry directly aim to alter brain chemistry or function to alleviate mental health symptoms. This can involve medication, such as antidepressants, antipsychotics, or mood stabilizers; brain stimulation therapies like electroconvulsive therapy (ECT) or transcranial magnetic stimulation (TMS); or even surgery in rare, severe cases.
Physical Therapy
- Drug Treatment (Psychopharmacology)
- ElectroConvulsive Therapy
- Occupational Therapy
- Recreational Therapy
Drug Treatment (Psychopharmacology)
Antipsychotics (Neuroleptic) Drugs
Antipsychotics are psychiatric medications used to manage psychosis, which involves conditions like schizophrenia and bipolar disorder. These medications help treat symptoms such as delusions, hallucinations, paranoia, or confused thinking. Antipsychotic drugs, also known as neuroleptics, are mainly prescribed for conditions involving distorted reality, perception impairments, and severe mood disturbances. They are used for the following:
- Schizophrenia: Effective in treating both positive symptoms (e.g., hallucinations) and, with some drugs, negative symptoms (e.g., social withdrawal).
- Bipolar Disorder: Used alongside mood stabilizers to manage manic or depressive episodes.
- Psychosis in Dementia and Alzheimer’s Disease: Often used in low doses.
- Depression with Psychotic Features: Used as adjuncts in treatment-resistant cases.
- Other conditions: Used in agitation, delirium, and certain behavioral disorders.
Schizophrenia is a chronic psychotic illness characterized by a disintegration of the process of thinking, contact with reality, and emotional responsiveness. It is more common in males and usually begins in late adolescence to the early twenties.
Clinical Features of Schizophrenia
Clinical features of schizophrenia are often presented as positive or negative symptoms.
Positive Symptoms
- Delusions
- Hallucinations
- Thought disorders
- Disorganized behaviors
- Agitation
Negative Symptoms
- Lack of drive
- Apathy
- Social withdrawal
- Poor self-care
- Poverty of speech
Positive symptoms are seen as exaggeration of normal function and are common in the acute phase. Negative symptoms are viewed as loss of normal function and are prominent in the chronic phase. Most drugs are effective against positive symptoms except atypical antipsychotics such as olanzapine which are effective against both positive and negative symptoms. Drugs used in the treatment of schizophrenia can be classified as either typical (first generation) or atypical (second generation) antipsychotics.
| Class | Drug | Target Symptoms |
|---|---|---|
| Phenothiazines (Typical) | Chlorpromazine | Hallucinations Delusion Irrational behavior |
| Fluphenazine | ||
| Trifluoperazine | ||
| Promethazine | ||
| Thioridazine | ||
| Butyrophenone (Typical) | Haloperidol | Elevated mood, expansive self-image, grandiose delusion |
| Droperidol | ||
| Atypical Antipsychotic | Risperidone | Hallucinations, delusions |
| Clozapine | ||
| Olanzapine |
- Drug treatment must be started as soon as possible for better results
- Acute psychotic symptoms such as hallucination or delusions can be controlled using drugs such as haloperidol or chlorpromazine
- Positive symptoms tend to respond better to drugs than negative symptoms
- Treatment for schizophrenia is not curative and long-term maintenance therapy (2-5 years) is usually required to prevent relapse
Mechanism of Action
Antipsychotic drugs primarily target dopamine pathways in the brain, as excess dopamine activity is linked to psychotic symptoms. The main mechanisms include:
- Dopamine Receptor Blockade: Most antipsychotics work by blocking dopamine D2 receptors in the brain, especially in regions like:
- Basal Ganglia: Impacts motor function, often leading to motor side effects.
- Hypothalamus: Regulates endocrine and autonomic functions.
- Limbic System: Manages emotions and behavior, reducing hallucinations and delusions.
- Brain Stem: Helps in managing autonomic functions.
- Medulla: Involvement in central nervous system functions.
- Dopamine Transmission Inhibition: These drugs inhibit dopamine-mediated transmission in synapses, which helps decrease the excitation and abnormal activity associated with psychotic symptoms.
- Serotonin-Dopamine Interactions (Atypical Antipsychotics): Newer atypical antipsychotics often target both dopamine and serotonin receptors, providing a balanced mechanism that reduces psychotic symptoms with fewer side effects.
Antipsychotics primarily work by blocking dopamine receptors, particularly D2 receptors, in various brain pathways:
- Dopamine Blockade: Overactivity of dopamine in the mesolimbic pathway is thought to cause psychotic symptoms, so antipsychotics block D2 receptors in this area.
- Serotonin-Dopamine Antagonists (Atypicals): Newer drugs also block serotonin receptors (5-HT2A), which modulate dopamine levels more finely, reducing both psychotic symptoms and the side effects of dopamine blockade.
Other neurotransmitters affected include:
- Muscarinic acetylcholine receptors: Causes anticholinergic side effects.
- Histamine receptors: Leads to sedation and weight gain.
- Adrenergic receptors: Causes cardiovascular effects like hypotension.
The binding affinity of the typical is very strongly correlated with clinical antipsychotic and extrapyramidal potency: the typical antipsychotic drugs must be given in sufficient doses to achieve 60% occupancy of striatal D2 receptors.
They block 5-HT2A-receptors with lesser degree of antagonism of D2-receptor.
- Have efficacy against negative effects especially clozapine
- As a result, they have fewer extrapyramidal adverse effects than the older traditional agents.
- Atypical agents are serotonin-dopamine 2 antagonists (SDAS)
- They are considered atypical in the way they affect dopamine and serotonin neurotransmission in the four key dopamine path way in the brain.
Pharmacokinetics
- Absorption: Antipsychotics are generally absorbed well but incompletely, with significant first-pass metabolism reducing bioavailability (25-65%).
- Distribution: Highly lipid-soluble, protein-bound (92-98%), and large volumes of distribution (>7 L/Kg).
- Metabolism: Most antipsychotics are extensively metabolized in the liver, and some have active metabolites. For example, the metabolite of thioridazine, mesoridazine, is more potent.
- Excretion: Most of these drugs are excreted as metabolites, with a half-life of 10-24 hours, though their action often lasts longer due to the persistence of active metabolites.
Types and Examples of Antipsychotic Medications
Antipsychotics are generally divided into two major categories: typical (first-generation) and atypical (second-generation).
Typical (First-Generation) Antipsychotics
Older drugs that primarily act on dopamine receptors with potent effects on psychosis but higher risks of movement-related side effects.
- Mechanism: Predominantly act by blocking dopamine (D2) receptors in the mesolimbic system. This leads to a reduction in positive symptoms but often causes significant extrapyramidal side effects (EPS).
- Indications: Primarily effective against the positive symptoms of schizophrenia, such as hallucinations and delusions.
- Side Effects: Higher risk of EPS like Parkinsonism, dystonia, and tardive dyskinesia due to strong dopamine receptor blockade.
- Classes: Phenothiazines, Butyrophenones, Thioxanthines.
Common Medications:
- Haloperidol: Highly potent and commonly used in acute psychosis, available in injectable forms for emergencies.
- Chlorpromazine: Often used for sedation in psychosis; more sedative and lower potency than haloperidol.
- Trifluoperazine: Moderate potency with a focus on treating agitation and severe anxiety.
- Fluphenazine: Available as a long-acting injection, commonly used for maintenance therapy in chronic psychotic disorders.
Advantages:
- High availability and cost-effectiveness.
- Suitable for use in emergencies due to strong dopamine receptor antagonism.
- Injectable forms allow for extended control of symptoms.
Classes of Typical Antipsychotics
- Phenothiazines.
- Chlorpromazine (Thorazine)(Largactil)
- Fluphenazine (Prolixin)
- Perphenazine (Trilafon)
- Prochlorperazine (Compazine)
- Thioridazine (Mellaril)
- Trifluoperazine (Stelazine)
- Mesoridazine
- Promazine
- Triflupromazine (Vesprin)
- Levomepromazine (Nozinan)
- Promethazine (Phenergan)
Chlorpromazine (Largactil)
Chlorpromazine is in a phenothiazine group. It has high sedating properties but with low extra pyramidal side effects. It is absorbed in the jejunum (in the alimentary canal) and metabolized in the liver. Anti- depressants reduce
- Butyrophenones.
- Haloperidol (Haldol)
- Droperidol (Inapsine)
- Thioxanthones.
- Chlorprothixene
- Flupentixol (Depixol and Fluanxol)
- Thiothixene (Navane)
- Zuclopenthixol (Clopixol and Acuphase)
Thioxanthenes are psychotropic drugs in the neuroleptics group. They were the first neuroleptics to come into use. They are noted to have very gross side effects. With production of new neuroleptics drugs, the use of thioxanthenes has reduced.
Indications:
- Schizophrenia (chronic)
- Mania
- And other psychotic associated conditions.
Flupentixol (depixol)
Dose: 3mg-9mg. The maximum dose can be 18 mg in divided doses
N.B: avoid giving neuroleptic injectables by I.V route for the fear of postural hypotension.
Atypical (Second-Generation) Antipsychotics
These drugs have a broader mechanism, affecting both dopamine and serotonin pathways, making them less likely to cause severe motor side effects.
- Mechanism: Block both dopamine (D2) and serotonin (5-HT2A) receptors, improving both positive and negative symptoms with a lower risk of EPS.
- Indications: Effective in treating both positive and negative symptoms of schizophrenia. Also used in bipolar disorder, treatment-resistant depression, and psychosis in Alzheimer’s.
- Side Effects: Associated with metabolic disturbances such as weight gain, diabetes, and dyslipidemia.
- Classes: Dibenzodiazepines, Benzisoxazoles, Thienobenzodiazepines, among others.
Common Medications:
- Risperidone: Effective for both positive and negative symptoms with mild side effects.
- Olanzapine: Highly effective but may cause significant weight gain and metabolic issues.
- Clozapine: Reserved for treatment-resistant schizophrenia due to a risk of agranulocytosis; requires regular blood monitoring.
- Quetiapine: Known for its sedative effects, often used in acute settings or when sedation is desired.
Advantages:
- Lower risk of extrapyramidal symptoms (EPS).
- Effective in treating negative symptoms (social withdrawal, lack of motivation) in schizophrenia.
- Broader mechanism of action may help treat bipolar and depressive psychotic symptoms.
Atypical or second generation or novel
Atypical or ‘2nd generation’. These medications have been used since the 1990s. These are newer types of antipsychotics.
- These are sometimes referred to as ‘atypicals’ These are newer antipsychotic drugs on the Ugandan market and are less commonly used because they are expensive. They are however the best antipsychotics because they control both negative and positive symptoms of schizophrenia. These drugs are also associated with fewer side effects compared to the typical antipsychotics. Are also called new antipsychotic drugs.
- Some are also less likely to cause sexual side effects compared to first generation antipsychotics.
But second generation antipsychotics may be more likely to cause serious metabolic side effects. This may include rapid weight gain and changes to blood sugar levels, diabetes mellitus, hypercholesterolemia.
Classes of Atypical Antipsychotics
- Benzoxazoles- Risperidone
- Dibenzodiazepines – Clozapine
- Thienobenzodiazepine- Olanzapine
- Dibenzothiazepine- Quetiapine
- Imidazolidinone – Sertindole
Risperidone (Risperdal)
- Available in regular tabs, I.M depot form and rapidly dissolving tablet.
- Functions more like atypical antipsychotic at doses greater than 6 mg.
- Increased extra pyramidal side effects (dose dependent)
- Most likely atypical to induce hyperprolactinemia.
- Weight gain and sedation (dose dependent)
- Hypotension, fatigue, abdominal pain, nausea.
Olanzapine (Zyprexa)
- Available in regular tabs, immediate release I.M, rapidly dissolving tab, depot form. Dose 5mg-20mg/ day-OD /nocte.
Adverse Side Effects of Antipsychotics
Antipsychotic medications, especially typical antipsychotics, can cause a range of side effects, some of which may be serious. Side effects are classified into several categories based on their mechanism and impact on patient health.
Extrapyramidal Symptoms (EPS)
These are motor-related side effects resulting from dopamine blockage in pathways associated with movement.
- Neuroleptic-Induced Parkinsonism.
- Symptoms: Rigidity, tremors, bradykinesia (slowed movement), stooped posture, drooling, akinesia (loss of movement), and ataxia.
- Management: Treated with anticholinergic agents (e.g., Benztropine) or medications like amantadine.
- Acute Dystonia: Involuntary muscle contractions affecting the neck, jaw, tongue, and sometimes entire body. Severe cases involve oculogyric crisis (eyes rolled upward).
- Treatment: Often managed with anticholinergics, antihistamines (e.g., diphenhydramine), beta-blockers, benzodiazepines, or dopamine agonists to relax muscles.
- Akathisia: A feeling of intense restlessness, often leading to pacing or repetitive movements, contributing to patient discomfort.
- Symptoms: Foot stamping when seated. Constantly crossing or uncrossing legs. Rocking from foot to foot. Constantly pacing up and down.
- Treatment: Commonly treated with beta-blockers (e.g., propranolol), benzodiazepines, and clonidine.
- Management: Reduce or lower the antipsychotic dose. Give benzodiazepines like diazepam. Give beta blockers like propranolol. Give an anti cholinergic like artane.
- Tardive Dyskinesia: A delayed, potentially irreversible side effect involving abnormal, involuntary movements such as lip-smacking, grimacing, tongue thrusting, and irregular limb movements.
- Rabbit syndrome: lip smacking or chewing type movement as of a rabbit.
- Tongue protrusion: fly catching.
- Choreiform hand movements (pill rolling or piano playing)
- Severe orofacial movement can lead to difficulty, speaking, eating, or breathing. Movements are worse when under stress.
- Prevention and Management: No definitive treatment, but reducing the dose or switching to atypical antipsychotics may help; valbenazine and deutetrabenazine are also FDA-approved for managing tardive dyskinesia.
- Management: Stop anti-cholinergic if prescribed. Reduce dose of anti psychotic. Change to a typical drug.
- Neuroleptic Malignant Syndrome (NMS): A life-threatening reaction often occurring within the first two weeks of treatment.
- Symptoms: Severe muscle rigidity, hyperthermia, altered mental status, autonomic instability (unstable BP, tachycardia), excessive sweating, and urinary incontinence.
- Management: Requires immediate discontinuation of antipsychotic, supportive care (IV fluids, cooling), and administration of drugs like dantrolene or bromocriptine in severe cases.
Autonomic Side Effects
- Dry Mouth, Constipation, and Blurred Vision: Due to anticholinergic properties of certain antipsychotics.
- Urinary Retention and Orthostatic Hypotension: Especially common in drugs like chlorpromazine.
- Impotence and Ejaculation Problems: Related to autonomic nervous system effects.
Other Side Effects
- Seizures: Increased Seizure Risk: Some antipsychotics lower the seizure threshold, particularly clozapine, necessitating caution in patients with seizure history.
- Sedation: Cause: Sedative effects are more pronounced with certain antipsychotics (e.g., chlorpromazine, quetiapine) due to their antihistaminergic action. Implication: While sometimes beneficial in agitated patients, sedation can interfere with daily functioning.
- Metabolic and Endocrine Effects: Weight Gain and Metabolic Syndrome: More common in atypical antipsychotics (e.g., olanzapine, clozapine), with risks of diabetes and hyperlipidemia. Hyperprolactinemia: Elevated prolactin levels causing galactorrhea, gynecomastia, and sexual dysfunction.
- Hematologic Effects: Agranulocytosis: A serious side effect of clozapine, characterized by a drop in white blood cells, requiring regular monitoring. Leukopenia and Neutropenia: Possible with both typical and atypical antipsychotics, increasing infection risk.
- Dermatological Effects: Photosensitivity: Certain antipsychotics (e.g., chlorpromazine) may increase sensitivity to sunlight. Dermatitis: Contact dermatitis may occur due to long-term use.
- Gastrointestinal and Hepatic Effects: Sialorrhea: Increased salivation, especially with clozapine, which can cause discomfort and swallowing issues. Jaundice: Rarely, some antipsychotics may induce jaundice due to liver enzyme alterations.
- QT Prolongation: Risk of fatal arrhythmias, especially with drugs like haloperidol.
- Anticholinergic Side Effects: Dry mouth, constipation, blurred vision, and urinary retention, particularly in elderly patients.
Monitoring and Management
Regular monitoring is essential when prescribing antipsychotics. This includes:
- Clinical assessment of psychotic symptoms: Tracking the effectiveness of the medication.
- Monitoring for adverse effects: Regular physical examinations, blood tests (complete blood count, liver function tests, lipid panel, fasting blood glucose), and electrocardiograms (ECGs) may be necessary.
- Prolactin levels: For women of childbearing age.
- Weight and BMI: Regularly monitoring to detect weight gain.
- Metabolic testing: Regular blood work to assess for metabolic syndrome.
Depot Antipsychotics
Depot injections are long-acting formulations that ensure consistent drug delivery over weeks, especially beneficial for patients with poor adherence to oral medications. Common depot drugs include fluphenazine decanoate and haloperidol decanoate.
ANTIPSYCHOTIC DEPOT INJECTIONS (LONG ACTING)
These are antipsychotics given by injection I.M. They are oily in nature and therefore, slowly released and metabolized over a period of 2 weeks up to 4 weeks.
Indications
- Chronic schizophrenia
Advice on prescribing depot injection/ medication:
- Give a test dose.
- Begin with the lowest therapeutic dose.
- Administer at the longest possible licensed interval
- Adjust doses only after an adequate period of assessment
circumstances e.g. long interval necessitates high volume ( >3-4 ml) injection.
Haloperidol
Available Preparations:
- Tablets: 5 mg, 10 mg
- Injection: 5 mg/ml, 50 mg/ml
Available Brands: Decanoas®, Haldol®, Haloxen®, Haldol
Pharmacokinetics: Haloperidol is relatively well absorbed following oral administration, distributed widely into the body, with high concentrations in adipose tissue. It is metabolized by the liver and excreted in urine and a small amount in feces.
Indications:
- Schizophrenia
- Behavior disturbance
- Nausea and vomiting
- Mania
- Severe anxiety
- Intractable hiccups
Contraindications:
- CNS depression
- Comatose states
- Severe hepatic disease
- Known hypersensitivity to haloperidol
Dosage:
Oral:
- Schizophrenia and Other Psychosis, Mania, Psychomotor Agitation, Violent Behavior, and Severe Anxiety (Adjunct): Adult: Initially 0.5-5 mg 2-3 times daily, increased as needed up to 20 mg/day, maintenance usually 2-10 mg/day
- Acute Psychosis: 2-10 mg IM 6-8 hourly interval until symptoms are controlled
- Long-term Therapy: 10-20 mg up to max of 100 mg deep IM of decanoate injection may be given
- Nausea and Vomiting: 0.5-2 mg daily by IM injection
- Intractable Hiccups: Orally 0.5 mg 3 times daily, adjusted according to response
IM or Slow IV Injection:
- Acute Psychosis: 2-10 mg IM 6-8 hourly interval until symptoms are controlled
Side Effects:
- Dry mouth
- Weight gain
- Lethargy
- Sedation
- Restlessness or akathisia
- Constipation
- Muscle stiffness
- Hypotension
- Muscle cramping
- Blurred vision
- Increased appetite
- Tinnitus
- Swelling of female breasts
- Depression
- Decreased sexual function
- Peripheral edema
Drug Interactions:
- Alcohol and other CNS depressants may increase CNS depression
- Rifampicin accelerates the metabolism of haloperidol resulting in reduced plasma concentration
- Haloperidol enhances the hypotensive effect of prazosin
- Haloperidol enhances the sedative effect of clonazepam, codeine, and diazepam
- Carbamazepine accelerates the metabolism of haloperidol
- Haloperidol may inhibit blood pressure response to centrally acting antihypertensives such as methyldopa
- Beta blockers may inhibit haloperidol metabolism, increasing plasma levels and toxicity
- Haloperidol may antagonize the therapeutic effect of bromocriptine on prolactin secretion
- Haloperidol may inhibit metabolism and increase toxicity of phenytoin
Key Issues to Note:
- Tardive dyskinesia may occur after prolonged use and may disappear spontaneously or persist for life
- Protect the drug from light; slight yellowing of the injection is common and does not affect potency
- Advise the patient to report side effects such as extrapyramidal reactions
- Elderly patients usually require lower initial doses and a more gradual dosage adjustment
- The drug is not recommended for children under 3 years because they are prone to extrapyramidal reactions
- Avoid alcohol and other medications that cause sedation
Drugs and Their Dosages
| Drug | Type | Dosage | Forms | Indications | Side Effects | Contraindications |
|---|---|---|---|---|---|---|
| Chlorpromazine | Typical | Oral, IM, suppository | Schizophrenia, mania, intractable hiccups | Sedation, hypotension, dry mouth | Liver disease, glaucoma | |
| Haloperidol | Typical | Oral, IM, depot | Schizophrenia, agitation, nausea | High EPS, low sedation | Parkinsonism, QT prolongation | |
| Olanzapine | Atypical | Oral, IM, depot | Schizophrenia, bipolar disorder | Weight gain, diabetes | Severe liver dysfunction | |
| Clozapine | Atypical | Oral | Treatment-resistant schizophrenia | Agranulocytosis, sedation, seizures | Bone marrow suppression, seizures | |
| Risperidone | Atypical | Oral, depot | Schizophrenia, bipolar mania | Weight gain, hyperprolactinemia | Severe hepatic or renal impairment |
Antidepressants
Drugs Used in the Treatment of Depression
Depression is a mental state characterized by diverse psychological symptoms such as low mood, loss of interest and enjoyment of activities, and reduced energy. Depression is associated with physical symptoms such as:
- Fatigue
- Anxiety
- Sleep disturbance
- Reduction in libido
- Decreased productivity
- Changes in appetite or weight
- Loss of concentration
- Loss of interest (depressed mood)
- Thoughts of death and suicide
Drugs used in the treatment of depression include:
- Tricyclic antidepressants
- Selective Serotonin Reuptake Inhibitors (SSRIs)
- Monoamine Oxidase Inhibitors (MAOIs)
- Other antidepressant drugs (Atypical antidepressants)
Tricyclic Antidepressants
These drugs inhibit the reuptake of norepinephrine and serotonin at the presynaptic neuron, prolonging neuronal activity.
Examples:
- Amitriptyline
- Imipramine
- Clomipramine
Amitriptyline
Available Preparations:
- Tablets: 25 mg
Available Brands: Laroxyl®
Pharmacokinetics: Amitriptyline is absorbed rapidly from the GIT, distributed widely into the body, including the CNS and breast milk, metabolized in the liver to active metabolites, and excreted in urine.
Indications:
- Depression where sedation is required
- Nocturnal enuresis in children
- Peripheral neuropathy
- Post-herpetic neuralgia
- Migraine prophylaxis
- Tension headache
- Adjuvant in pain management
Contraindications:
- Known hypersensitivity to the drug
- Recent myocardial infarction
- Severe liver disease
- Manic phase
- Coma or severe respiratory depression
- Prostatic hypertrophy
- Glaucoma
Dosage:
Depression:
- Adult: Initially 75 mg daily in divided doses or as a single dose at bedtime. Increased gradually according to response to 150 mg.
Nocturnal Enuresis:
Children:
- 7-10 years: 10-20 mg at night
- 11-16 years: 25-50 mg at night. Maximum period of treatment is 3 months.
Peripheral Neuropathy: Initially 10-25 mg daily at night, increased if necessary to 75 mg daily.
Migraine Prophylaxis: Initially 10 mg at night, increased according to response to a maintenance dose of 50-75 mg at night.
Adjuvant Pain Management: 10-25 mg at night, up to a max of 150 mg.
Side Effects:
- Dry mouth
- Sedation
- Constipation
- Postural hypotension
- Difficulty with micturition
- Blurred vision
- Cardiac arrhythmias
- Unpleasant taste
- Somnolence
- Photosensitivity
- Interference with sexual function
- Nausea
- Tremors
- Sweating
- Skin rashes
- Headache
- Urticaria
- Hypomania
- Weight gain
- Increased appetite
Drug Interactions:
- Cimetidine, valproic acid may increase amitriptyline blood concentration and risk of toxicity
- Alcohol, anticonvulsants, phenothiazines, and sedative hypnotics may increase CNS depression caused by amitriptyline
- Carbamazepine reduces the serum concentration of amitriptyline
- Concurrent use of amitriptyline with phenylephrine, ephedrine may increase blood pressure
- Amitriptyline may decrease the hypotensive effect of methyldopa
Key Issues to Note:
- Inform the patient that full therapeutic effect may delay up to 4 weeks
- Avoid alcoholic beverages while taking this drug
- Warn the patient not to stop taking the drug suddenly
- The drug causes drowsiness and may impair activities that need mental alertness
Selective Serotonin Reuptake Inhibitors (SSRIs)
Their efficacy is similar to that of tricyclic antidepressants but with fewer side effects because of low affinity for muscarinic, histaminergic, and adrenergic receptors.
Examples:
- Fluoxetine
- Paroxetine
- Sertraline
- Citalopram
Mode of Action
The antidepressant action of SSRIs is by inhibiting the reuptake of the neurotransmitter serotonin.
Fluoxetine
Available Preparations:
- Capsules: 20 mg
Available Brands: Prozac®, Nuzac®, Trizac®, Fludac®, Flocept®
Pharmacokinetics: Fluoxetine is well absorbed after oral administration, metabolized in the liver to active metabolites, and excreted in urine.
Indications:
- Major depression
- Obsessive-compulsive disorder
- Bulimia nervosa
- Premenstrual dysphoric disorder
- Panic disorders
- Post-traumatic stress disorder
- Hot flushes
Contraindications:
- Hypersensitivity to fluoxetine
- Severe renal failure
- Unstable epilepsy
- Manic phase
Dosage:
- Depression: 20 mg once daily, increased after 3-4 weeks if necessary. Find at appropriate intervals thereafter, max 60 mg once daily.
- Elderly: 20-40 mg once daily, max 60 mg.
- Bulimia Nervosa: 60 mg once daily, max 80 mg once daily.
- Obsessive-Compulsive Disorder: Initially 20 mg once daily, increased after 2 weeks if necessary, max dose 60 mg. Elderly: 20-40 mg once daily, max 60 mg.
- Panic Disorders: 10 mg once daily, do not exceed 20 mg daily.
- Premenstrual Dysphoric Disorder: 20 mg once daily.
Side Effects:
- Headache
- Insomnia
- Somnolence
- Constipation
- Abdominal pain
- Dry mouth
- Dizziness
- Anxiety
- Tremor
- Sedation
- Fatigue
- Mania
- Sweating
- Pharyngitis
- Euphoria
- Dyspnea
- Nervousness
- Sleep disturbance
- Drowsiness
Drug Interactions:
- Alcohol and other CNS depressants may increase CNS depression
- Fluoxetine may increase phenytoin blood concentration and risk of toxicity
- Fluoxetine may increase the effect of warfarin; therefore, the dose may need adjustments
- Fluoxetine may increase the blood levels and toxicity of lithium
- Fluoxetine inhibits the metabolism of carbamazepine and haloperidol
Key Issues to Note:
- Full antidepressant effect may be delayed until 4 weeks of treatment
- Give a lower dose in patients with hepatic and renal impairment
- Avoid taking alcohol during drug therapy
Mood Stabilizers
Drugs Used in the Treatment of Manic Disorders
Mania is a state of mind characterized by excessive cheerfulness and increased activity.
Signs and Symptoms:
- Hyperactivity
- Excessive enthusiasm
- Decreased need for sleep
- Flight of ideas
- Inflated self-esteem
- Talkativeness
- Extreme self-confidence
- Delusions
Acute mania usually begins abruptly and symptoms increase over several days. Manic episodes may be precipitated by:
- Use of antidepressants
- Lack of enough sleep
- Stressors
- CNS stimulants
- Bright light
Bipolar disorder (manic depression) is a mixed affective disorder in which the patient experiences alternating episodes of hypomania or mania and depression.
Management of Manic Disorders:
- Mild Symptoms of Mania: Lithium alone or in combination with benzodiazepine
- Severe Symptoms of Mania: Lithium plus antipsychotic drugs
Note: In acute attack of mania, lithium carbonate may be given concurrently with antipsychotic in order to bring the symptoms under control. Lithium carbonate has a slow onset of action which takes up to 2 weeks before therapeutic benefit is fully achieved.
Drugs used in the treatment of mania include:
- Lithium carbonate
- Sodium valproate
- Carbamazepine
- Lamotrigine
Lithium Carbonate
Available Preparations:
- Tablets: 300 mg
Available Brands: Camcolit®
Pharmacokinetics: It is completely absorbed from the GIT after oral administration, distributed widely into the body including breast milk. It is not metabolized and is excreted unchanged in urine.
Indications:
- Prophylaxis of mania
- Treatment of acute mania
- Manic phase of bipolar disorder
- Recurrent depression
- Aggressive or self-mutilating behavior
Contraindications:
- Pregnancy
- Severe renal impairment
- Cardiac disease
- Lactation
- Untreated hypothyroidism
- Disturbance of electrolyte balance
- Hypersensitivity to the drug
Dosage:
Adult and Children over 12 years:
- Acute Mania: 300 mg 3-4 times, maintenance dose 2.4 g/day.
- Prophylaxis: Initially 300-400 mg daily.
Side Effects:
- Nausea
- Diarrhea
- Muscle weakness
- Polyuria
- Vertigo
- Tremors
- Loss of concentration
- Hypothyroidism
- Impaired renal function
- Hypermagnesemia
- Disturbances of thyroid function
- Exacerbation of psoriasis
- Weight gain
- Oedema
- Mild drowsiness
- Sexual dysfunction
Drug Interactions:
- Concurrent use of lithium with thiazide diuretics may decrease renal excretion and enhance lithium toxicity
- Lithium may interfere with pressor effects of sympathomimetic agents and may decrease the effects of chlorpromazine
- Tetracyclines, phenytoin, carbamazepine, and methyldopa may increase lithium toxicity
- Concomitant use with haloperidol or other antipsychotic agents may result in severe encephalopathy
- Use of lithium with SSRIs may increase GI and CNS adverse effects
- Indometh
Anxiolytics, Sedatives, and Hypnotics
Anxiety is an emotional condition characterized by feelings such as apprehension and fear, accompanied by symptoms such as tachycardia, increased respiration, sweating, and tremor.
Drugs used in the treatment of anxiety include:
- Benzodiazepines
- Antidepressants (Anxiety frequently co-exists with depression)
- Beta blockers (may help to control physical symptoms such as tremor)
Note:
- Antidepressants can initially exacerbate anxiety (their therapeutic response takes at least 2 weeks), therefore combined therapy with benzodiazepines may be required initially.
- Benzodiazepines should be used for a maximum of 4 weeks, and the dose should be gradually reduced after the first 2 weeks to avoid the risk of dependence.
Insomnia
Insomnia is the inability to achieve or maintain sleep. It often leaves sufferers feeling unrefreshed by sleep and may lead to impaired daytime performance.
Insomnia is classified as follows:
- Transient Insomnia: It may occur in those who normally sleep well and may be due to environmental stress such as noise, shift work, or jet lag. It may also be associated with acute disorders.
- Short-term Insomnia: It is often related to an emotional problem (e.g., ongoing personal stress) or medical illness such as acute pain.
- Chronic Insomnia: Most cases of chronic insomnia are caused by psychiatric disorders such as depression, anxiety, dementia, psychosis, or substance abuse, or physical causes such as pain or pruritus.
Drugs used in the treatment of insomnia include:
- Benzodiazepines
- Antidepressants
Benzodiazepines
This class includes:
- Diazepam
- Midazolam
- Bromazepam
- Alprazolam
- Clonazepam
- Nitrazepam
- Chlordiazepoxide
- Lorazepam
Diazepam
Available Preparations:
- Tablets: 5 mg
- Rectal: 10 mg
- Injection: 10 mg/2 ml
Available Brands: Valium®, Cozepam®, Solina®
Pharmacokinetics: Diazepam is rapidly absorbed from the GIT following oral administration, distributed widely throughout the body, metabolized in the liver to the active metabolite, and excreted in urine and a small amount in feces.
Indications:
- Status epilepticus
- Febrile convulsions
- Convulsions due to poisoning
- Anxiety disorders
- Insomnia
- Control of muscle spasms
- Management of alcohol withdrawal
Contraindications:
- Hypersensitivity to diazepam
- Respiratory depression
- Severe hepatic impairment
- Acute pulmonary insufficiency
- Sleep apnea
- Comatose patients
- Acute narrow-angle glaucoma
- Acute alcohol intoxication
- Infants less than 1 month
Dosage:
Oral:
- Anxiety: 2-10 mg 2-4 times daily
- Insomnia Associated with Anxiety: 5-15 mg at bedtime
- Muscle Spasms: 2-10 mg 2-4 times a day
- Acute Alcohol Withdrawal: 10 mg 2-4 times for the first 24 hours, reduce to 5 mg 3-4 times on the next day as required
- Severe Acute Anxiety, Control of Acute Panic Attacks, Acute Alcohol Withdrawal, Muscle Spasms: By IM or slow IV injection: 10 mg repeated if necessary after not less than 4 hours
- Status Epilepticus: By slow IV at a rate of 5 mg/min Adult: 10-20 mg repeated if necessary after 30-60 minutes Children: 200-300 mcg/kg or 1 mg/year of age
- Seizures Associated with Poisoning: By slow IV at a rate of 5 mg/min Adult: 10-20 mg
By Rectum as a Rectal Solution:
- Adult and Children over 3 years: 10 mg, repeat the dose after 5 minutes if necessary
- Children 1-3 years and elderly: 5 mg, repeat the dose after 5 minutes if necessary
Side Effects:
- Drowsiness
- Sedation
- Dependence
- Muscle weakness
- Hypotension
- Visual disturbance
- Changes in libido
- Urinary retention or incontinence
- Hypersensitivity reactions
- Ataxia
- Headache
- Confusion
- Vertigo
- Skin rash
- Tremor
- Blood disorders
- Amnesia
Drugs Used in the Treatment of Epilepsy
Epilepsy is a disorder of brain function characterized by recurrent seizures that have a sudden onset. A patient should not be described as having epilepsy until a second non-febrile seizure occurs.
Seizure: A seizure is a paroxysmal discharge of cerebral neurons accompanied by a clinical phenomenon apparent to the patient or to an observer.
Classification of Epilepsy
Epileptic seizures (fits) present in several different forms depending on the site of the discharge and whether the discharge remains localized or spreads.
Partial Seizures
These are epileptic seizures in which the neuronal discharge remains localized in one area of the brain. They result in a disturbance of function such as abnormal sensation or movement of the limb without loss of consciousness. Partial seizures are subdivided as follows:
- Simple partial seizures (consciousness is not impaired)
- Complex partial seizures (consciousness is impaired)
Partial seizures may become secondarily generalized seizures if the neuronal discharge spreads to involve the entire brain.
Generalized Seizures
Generalized seizures are characterized by a neuronal discharge involving the whole brain with loss of consciousness. They are subdivided as follows:
- Tonic-clonic seizures (grand mal)
- Myoclonic seizures
- Atonic seizures
- Absence seizures (petit mal)
Absence Seizures (Petit Mal)
These are generalized seizures characterized by a sudden loss of consciousness lasting for a few seconds. It is usually accompanied by motor activity which may vary from eyelid blinking to more extensive tonic body movement. It is common in children and juveniles.
Myoclonic Seizures
These are characterized by brief jerks in the limbs which may be single or multiple. The duration of the seizure is a few seconds. It mainly occurs in children and juveniles.
Atonic Seizures
Atonic seizures are characterized by loss of postural tone; the head sags or the patient falls down.
Generalized Tonic-Clonic Seizures (Grand Mal Fits)
These are characterized by a sudden attack with loss of consciousness and violent body jerking lasting 3-5 minutes. The patient regains consciousness spontaneously; incontinence, tongue biting, or other injuries may occur during the episode. Grand mal fits may be due to:
- Family history of epilepsy
- Uncontrolled febrile convulsions in children
- Head injuries
- Infections (e.g., meningitis, HIV)
- Birth trauma to an infant
- Alcohol and drug abuse
Status Epilepticus
It is a seizure lasting for more than 30 minutes or several fits following one another without restoration of consciousness in between the fits. Status epilepticus is a common complication of grand mal epilepsy and it’s a medical emergency.
Management of Status Epilepticus
- Position the patient to avoid injury
- Give oxygen to support respiration
- If hypoglycemia is suspected, give a bolus of 50 ml of 50% glucose IV
- Consider giving parenteral thiamine if alcohol abuse is suspected
- Give anticonvulsants such as diazepam IV, lorazepam IV, clonazepam, midazolam
- Slow intravenous injection of phenytoin may be given if seizures recur or fail to respond to diazepam 30 minutes after it began
- Phenytoin by intravenous infusion should be given at a dose of 15 mg/kg body weight at a rate not greater than 50 mg/minute.
- Monitoring of blood pressure and ECG is necessary and phenytoin should be diluted with sodium chloride (normal saline) at a ratio of 1 mg of phenytoin: 1 ml of normal saline
Summary of Choices of Antiepileptic Drugs
| Seizure Type | Treatment Options |
|---|---|
| Partial Seizures | Carbamazepine, sodium valproate, pregabalin, lamotrigine, gabapentin, phenytoin |
| Generalized Tonic-Clonic Seizures (Grand Mal) | Carbamazepine, lamotrigine, sodium valproate, phenytoin |
| Absence Seizures (Petit Mal) | Ethosuximide, sodium valproate |
| Myoclonic Seizures | Sodium valproate, clonazepam |
| Status Epilepticus | Diazepam, clonazepam, midazolam, and phenytoin |
Carbamazepine
Available Preparations:
- Tablets: 100 mg, 200 mg
- Syrup: 20 mg/ml
Available Brands: Tegretol®, Storilat®, Carbatol®, Carbadac®, Carbazina®
Pharmacokinetics: It is absorbed slowly from the GIT, distributed widely throughout the body, crosses the placenta, and accumulates in fetal tissue. It is metabolized by the liver to an active metabolite and is excreted in urine and feces.
Indications:
- Partial and secondary generalized tonic-clonic seizures
- Mixed partial or generalized seizure disorder
- Trigeminal neuralgia
- Prophylaxis in bipolar disorder
- Neuropathic pain
- Alcohol withdrawal
Contraindications:
- Hypersensitivity to carbamazepine and TCAs
- History of bone marrow depression
- Porphyria
Dosage:
- Epilepsy: Initially 100-200 mg 1-2 times daily, increased gradually after 2 weeks to the usual dose 400-1200 mg daily in divided doses. In some cases up to 1.6-2 g daily may be needed.
- Elderly: Initially 50 mg twice daily then increase to 400-1200 mg daily.
- Children 1 month – 12 years: Initially 5 mg/kg at night or 2.5 mg/kg twice daily, increased as necessary by 2.5-5 mg/kg every 3-7 days. Maintenance dose 5 mg/kg 2-3 times daily. Doses up to 20 mg/kg daily may be used.
- Trigeminal Neuralgia: Initially 100 mg 1-2 times daily, increased gradually according to response to 200 mg 3-4 times daily. Up to 1 g daily may be required in some cases.
- Prophylaxis of Bipolar Disorder Unresponsive to Lithium: Initially 400 mg daily in divided doses, increased until symptoms are controlled. Usual range 400-600 mg daily, max 1.6 g daily.
- Neuropathic Pain: Initially 100 mg twice daily, increased gradually until pain is relieved. Maintenance dose 200-600 mg daily. Do not exceed 1.2 g daily.
Side Effects:
- Nausea
- Ataxia
- Vomiting
- Dizziness
- Drowsiness
- Dry mouth
- Blurred vision
- Headache
- Anorexia
- Agitation
- Diarrhea
- Confusion
- Constipation
- Impotence
- Thrombocytopenia
- Arthralgia
- Stevens-Johnson syndrome
- Gynaecomastia
Drug Interactions:
- Clarithromycin, erythromycin, cimetidine, isoniazid may inhibit hepatic metabolism of carbamazepine with resultant increase of its serum concentration and toxicity
- Rifampicin, phenytoin, and phenobarbital may decrease serum concentrations of carbamazepine
- Antimalarial drugs may antagonize the activity of carbamazepine
- Use with alcohol and other CNS drugs may potentiate adverse effects of carbamazepine
- Use with verapamil may significantly increase the serum levels of carbamazepine
- Carbamazepine may decrease the effectiveness of theophylline and oral contraceptives
- Carbamazepine may increase the metabolism of warfarin, valproic acid, haloperidol, and phenytoin
Key Issues to Note:
- Take carbamazepine with food to prevent stomach upset
- Swallow controlled-release tablets whole, do not chew or crush them
- Grapefruit juice may increase the absorption and blood concentration of carbamazepine
- The drug is structurally similar to TCAs; some risk of activating latent psychosis or agitation in elderly patients exists
- Avoid alcohol during therapy
- The drug may cause drowsiness and impair ability to perform activities requiring mental alertness or physical coordination
- The drug may cause dry mouth and photosensitivity reactions
Phenytoin
Available Preparations:
- Tablets: 100 mg
- Injection: 50 mg/ml
Available Brands: Phenyto-S®, Epanutin®
Pharmacokinetics: It is absorbed slowly from the small intestine, distributed widely throughout the body, metabolized by the liver to inactive metabolites, and excreted in urine.
Indications:
- Generalized tonic-clonic seizures
- Partial seizures
- Status epilepticus
- Cardiac arrhythmias
- Trigeminal neuralgia or severe pain
- Control of seizures associated with neurosurgery or traumatic injury to the head
Contraindications:
- Hypersensitivity to phenytoin or other hydantoins
- Sinus bradycardia
- Avoid parenteral use in sinus bradycardia
- Sino-atrial block
- 2nd and 3rd degree heart block
- Stokes-Adams syndrome (IV)
- Hepatitis
Dosage:
Oral:
- Adult: Initially 150-300 mg daily as a single dose or in 2 divided doses, increased gradually according to response to the usual dose 200-500 mg daily.
- Children: Initially 5 mg/kg daily in 2 divided doses, usual dose range 4-8 mg/kg daily, max 300 mg daily.
Arrhythmias:
- Adults: Loading dose 250 mg 4 times a day for 1 day, then 250 mg/day for 2 days, maintenance dose 300-400 mg/day 1-4 times a day.
Side Effects:
- Gastric intolerance
- Drowsiness
- Confusion
- Slurred speech
- Gum hyperplasia
- Headache
- Sedation
- Insomnia
- Blurred vision
- Skin rashes
- Acne
- Hirsutism
- Nausea
- Nystagmus
- Vomiting
- Diplopia
- Behavioral disturbance
- Tremors
- Anorexia
- Constipation
- Blood disorders
- Coarse facies
- Fever
Drug Interactions:
- Alcohol and other CNS depressants may increase CNS depression
- Anticoagulants, cimetidine, fluoxetine, fluconazole, ketoconazole, isoniazid, and sulphonamides may increase phenytoin blood concentration and risk of toxicity
- Lidocaine, propranolol may increase cardiac depressant effects caused by phenytoin
- Phenytoin may decrease the effects of oral contraceptives, corticosteroids, haloperidol, furosemide, doxycycline, etc.
- Therapeutic effects of phenytoin may be decreased by barbiturates, carbamazepine, ethanol, folic acid, antacids, charcoal, and pyridoxine among others
Key Issues to Note:
- To ensure consistent absorption, phenytoin should be administered at the same time with regards to meals
- Phenytoin may be taken with food or milk to decrease GI upset
- Avoid alcohol during therapy
- Abrupt withdrawal may precipitate status epilepticus
- Advise the patient to maintain good oral hygiene
Sodium Valproate
Available Preparations:
- Tablets: 200 mg, 300 mg
- Syrup: 200 mg/5 ml
Available Brands: Epilim®, Petilin®, Valparin Chrono®
Indications:
- Generalized tonic-clonic seizures
- Partial seizures
- Atonic seizures
- Absence seizures
- Myoclonic seizures
- Acute manic phase of bipolar disorder
- Prophylaxis of migraine
Contraindications:
- Hypersensitivity to sodium valproate
- Family history of severe hepatic dysfunction
- Pregnancy
- Active liver disease
- Porphyria
- Pancreatitis
Dosage:
- Adult: Initially 600 mg daily in 2 divided doses, preferably after food, increased by 200 mg daily every 3 days to a max of 2.5 g daily, usual maintenance dose 1-2 g daily.
- Children under 12 years with body weight over 20 kg: Initially 400 mg daily in divided doses, increased according to response, usual range 20-30 mg/kg daily, max 35 mg/kg daily.
- Children < 20 kg: Initially 20 mg/kg daily in divided doses.
Side Effects:
- Nausea
- Vomiting
- Increased appetite
- Abdominal cramps
- Sedation
- Thrombocytopenia
- Behavioral disturbance
- Hyperammonemia
- Menstrual disturbances
- Tremor
- Ataxia
- Oedema
- Diarrhea
- Weight gain
- Gastric irritation
- Transient hair loss
- Drowsiness
Drug Interactions:
- Sodium valproate increases plasma concentrations of phenobarbital, primidone, phenytoin, zidovudine
- Aspirin may increase the effect of sodium valproate
- Sodium valproate absorption may be reduced by colestyramine
- Cimetidine and erythromycin may increase the effect of sodium valproate
- Concomitant use with clonazepam may cause absence seizures
- Antacids may increase the oral absorption of sodium valproate
Key Issues to Note:
- Avoid alcohol during therapy
- The drug may cause drowsiness and impair ability to perform activities requiring mental alertness or physical coordination
- The drug should not be withdrawn abruptly
Phenobarbitone
Available Preparations:
- Tablets: 30 mg
Available Brands: B-tone®
Pharmacokinetics: Phenobarbitone is well absorbed after oral administration, distributed widely to body tissues, metabolized by the liver, and excreted in urine.
Indications:
- Generalized tonic-clonic seizures
- Partial seizures
- Neonatal seizures
- Febrile convulsions
- Status epilepticus
Contraindications:
- Hypersensitivity to phenobarbitone
- Absence seizures
- Porphyria
- Respiratory depression
- Severe liver impairment
Dosage:
Generalized Tonic-Clonic Seizures, Partial Seizures:
- Adult: 60-180 mg once daily at night
- Children: 5-8 mg/kg daily
Electroconvulsive Therapy (ECT)
Electroconvulsive therapy (ECT) is a medical procedure involving the induction of a controlled seizure using electrical currents passed through the brain. While its mechanism isn’t fully understood, it’s a highly effective treatment for specific mental health conditions. This guide provides a detailed overview, encompassing indications, contraindications, procedure, nursing care, and potential complications.
I. Introduction to ECT
- Definition: ECT is a physical therapy utilizing electrodes to deliver an electrical current to the brain, inducing a generalized seizure. This seizure is believed to trigger therapeutic changes in brain chemistry and function.
- Modified ECT: Modern ECT is a carefully controlled procedure performed under general anesthesia, minimizing discomfort and risk.
- Multidisciplinary Team: ECT requires a specialized team including an anesthesiologist, psychiatrist, registered nurses (RNs) skilled in ECT, and potentially other healthcare professionals such as respiratory therapists. The RN/RM plays a big role in pre-treatment preparation, intra-procedural monitoring, and post-treatment care.
II. Indications for ECT
ECT is considered a first-line or primary treatment for severe cases where other treatments have failed or are unsuitable. Its effectiveness often surpasses that of antidepressant medications, especially in acute situations:
- Severe Major Depressive Disorder (MDD): Especially when accompanied by psychotic features, suicidal ideation, or catatonia.
- Acute Manic Episodes: In bipolar disorder, particularly when severe or unresponsive to other treatments.
- Mood Disorders with Psychotic Features: Hallucinations or delusions accompanying mood disturbances.
- Treatment Intolerance or Resistance: When patients cannot tolerate or do not respond to other treatments, including medications, psychotherapy, or other somatic therapies.
- Suicidal Ideation or Severe Lethargy: ECT can rapidly alleviate profound depression and reduce suicidal risk.
- Catatonia: A state of immobility and unresponsiveness.
- Postpartum Psychosis: Severe mental illness occurring after childbirth.
- Treatment-Resistant Schizophrenia: In cases where typical antipsychotics and other treatments have proven ineffective.
III. Contraindications to ECT
Absolute contraindications are rare but include conditions that could be exacerbated by the procedure:
- Increased Intracranial Pressure (ICP): Conditions such as brain tumors, recent strokes, or severe head injuries raise ICP, making ECT risky.
- Recent Myocardial Infarction (MI): The stress of ECT could potentially trigger cardiac complications in patients who have recently had a heart attack.
- Uncontrolled Hypertension: High blood pressure needs to be stabilized before ECT is considered.
- Significant Cardiovascular Disease: Severe heart conditions may pose significant risks.
- Uncontrolled Epilepsy: While ECT may treat depression in people with epilepsy, it carries the risk of inducing further seizures in those with poorly controlled epilepsy.
- Aneurysms (Brain or Aortic): The procedure could cause rupture of aneurysms.
- Severe Respiratory Conditions: Conditions that might interfere with respiration during the procedure.
IV. Mechanism of Action
The precise mechanism of ECT remains under investigation. However, several theories exist:
- Neurotransmitter Modulation: ECT is believed to influence the levels and activity of neurotransmitters such as serotonin, norepinephrine, and dopamine, which are implicated in mood regulation.
- Neurogenesis and Neuroplasticity: Some research suggests that ECT may stimulate the growth of new neurons (neurogenesis) and enhance the brain’s ability to reorganize and adapt (neuroplasticity).
- Brain Storm Hypothesis: The induced seizure acts as a “brain reset,” disrupting maladaptive neural pathways associated with depression.
- Anti-inflammatory Effects: Recent research also indicates potential anti-inflammatory effects.
V. Procedure and Techniques
- Pre-Treatment Assessment: A thorough physical and psychiatric evaluation, including medication review and electrocardiogram (ECG).
- Informed Consent: Obtaining informed consent from the patient (when possible) or their legal guardian.
- Anesthesia: General anesthesia is administered to ensure patient comfort and safety. Muscle relaxants are also typically given to reduce muscle contractions during the seizure.
- Electrode Placement: Electrodes are placed on the scalp, usually bilaterally (on both sides of the head), although unilateral placement (one side) is also an option minimizing cognitive side effects.
- Electrical Stimulation: A brief electrical pulse is delivered, inducing a seizure lasting approximately 30-60 seconds. The seizure is monitored using EEG.
- Post-ECT Recovery: The patient is closely monitored in a recovery area until fully awake and stable.
VI. Indications for ECT (Detailed)
- Major Depressive Disorder: ECT is highly effective for severe, treatment-resistant depression, particularly when associated with psychotic features or suicidal ideation.
- Bipolar Disorder (Manic Phase): ECT can rapidly stabilize acute mania, especially when medication is ineffective or poorly tolerated.
- Schizophrenia: Useful in treatment-resistant cases, particularly when catatonia is present.
- Catatonia: ECT is often the first-line treatment for catatonia due to its rapid effects.
- Obsessive-Compulsive Disorder (OCD): May be helpful in treatment-resistant cases.
- Puerperal Psychosis: A severe mood disorder occurring after childbirth.
VII. Nursing Care in ECT (Detailed)
A. Pre-ECT
- Patient Education: Explain the procedure, including sensations, potential side effects, and post-ECT care. Address patient anxieties and concerns. Provide clear and concise information, using simple language.
- Assessment: Thoroughly assess the patient’s vital signs, medical history, medication list (including noting any recent changes), and mental status. Note any allergies, especially to anesthesia medications. Assess for any contraindications.
- NPO Status: Ensure the patient is NPO (nothing by mouth) for a specified period before the procedure, typically 6-8 hours.
- Consent: Ensure that informed consent has been obtained. Document the consent process thoroughly.
- Baseline Data: Record baseline vital signs, ECG, and any other relevant assessments.
- Preparation: Assist with the removal of any prostheses, jewelry, or glasses. Help the patient change into a gown and remove any metal objects from their clothing.
- Anxiety Management: Employ relaxation techniques such as deep breathing exercises or guided imagery to reduce anxiety.
B. During ECT
- Monitoring: Continuously monitor vital signs, ECG, EEG, and oxygen saturation during the procedure. Observe the patient’s response to the electrical stimulation and note the duration and characteristics of the seizure.
- Medication Administration: Assist the anesthesiologist in administering medications as prescribed (e.g., anesthetic agents, muscle relaxants).
- Positioning and Support: Properly position the patient to facilitate optimal electrode placement and seizure monitoring. Provide support and reassurance during the procedure.
- Emergency Preparedness: Remain vigilant for any complications, such as cardiac arrhythmias or respiratory distress, and be prepared to assist with emergency interventions as needed.
C. Post-ECT
- Recovery Monitoring: Closely monitor the patient’s vital signs, level of consciousness, and neurological status during the recovery period. This includes regular checks of oxygen saturation, heart rate, blood pressure, and respiratory rate. Note any signs of confusion, disorientation, or nausea.
- Post-Seizure Care: Provide suctioning as needed to clear any secretions. Administer oxygen if necessary.
- Reorientation: Assist the patient with reorientation to their surroundings as they regain consciousness.
- Pain Management: Assess for and manage any post-procedural pain or discomfort.
- Documentation: Accurately document all aspects of the patient’s care, including pre-procedure assessment, procedure details, post-procedure monitoring, and any complications or adverse events.
- Discharge Planning: Provide clear discharge instructions, including medication schedules, follow-up appointments, and potential side effects to watch out for.
VIII. Potential Complications
- Cognitive Impairment: Short-term memory loss is a common side effect, usually resolving within a few weeks. More significant cognitive deficits are less frequent.
- Headache: Many patients experience headaches after the procedure.
- Muscle aches: Muscle soreness can occur due to muscle relaxants.
- Nausea and Vomiting: These are relatively common side effects.
- Cardiac Arrhythmias: Rare but serious complications, necessitating close cardiac monitoring.
- Fractures: Rare, but the convulsive movements during a seizure could potentially cause fractures.
- Aspiration: There is a small risk of aspiration of vomit or secretions.
IX. Post-ECT Patient Education
- Memory Issues: Explain the temporary nature of memory loss and the likelihood of improvement. Encourage the patient to keep a diary or use memory aids if necessary.
- Medication Adherence: Emphasize the importance of continuing prescribed medications.
- Follow-up Appointments: Stress the importance of attending all scheduled appointments.
- Lifestyle Recommendations: Encourage healthy lifestyle choices, such as getting sufficient sleep and avoiding alcohol and other substances.
- Support Systems: Help the patient connect with support systems such as family, friends, or support groups.
X. Documentation
Comprehensive and meticulous documentation is essential. This includes:
- Pre-ECT assessment: Detailed medical history, medication list, allergies, vital signs, and mental status.
- Procedure details: Type of ECT (unilateral, bilateral), electrode placement, electrical parameters, seizure duration, and any complications during the procedure.
- Post-ECT monitoring: Vital signs, neurological assessment, level of consciousness, and any adverse events.
- Medication administration: Record all medications administered, including dosages and times.
Occupational Therapy
Occupational therapy (OT) is a therapeutic modality that focuses on helping patients develop, recover, or maintain daily living and work skills. OT is particularly beneficial for individuals with mental health conditions, as it promotes independence, self-esteem, and social integration.
Goals of Occupational Therapy
- Improve Daily Living Skills: Assist patients in managing activities of daily living (ADLs) such as dressing, grooming, and cooking.
- Enhance Cognitive Function: Improve memory, attention, and problem-solving skills through structured activities.
- Promote Social Skills: Encourage interaction with others through group activities and role-playing.
- Develop Vocational Skills: Help patients acquire or regain job-related skills to facilitate return to work or vocational training.
- Reduce Stress and Anxiety: Provide outlets for expression and relaxation through creative activities.
Techniques in Occupational Therapy
- Activity Analysis: Breaking down tasks into manageable steps to build confidence and skills.
- Adaptive Equipment: Recommending tools or modifications to make tasks easier (e.g., ergonomic utensils for eating).
- Group Therapy: Participating in group sessions to practice social skills and build support networks.
- Creative Activities: Engaging in art, music, or craft projects to express emotions and reduce stress.
- Vocational Training: Simulating work environments to prepare patients for employment.
Benefits of Occupational Therapy
- Increased Independence: Patients learn to perform tasks on their own, reducing reliance on others.
- Improved Self-Esteem: Achieving goals in therapy boosts confidence and sense of accomplishment.
- Better Social Integration: OT helps patients develop skills to interact effectively with others.
- Reduced Hospitalization: By improving coping skills, OT can prevent relapses and reduce the need for inpatient care.
Types of Occupational Therapy
Pediatric OT:
- Focus: Helps children with developmental issues such as ADHD, autism, cerebral palsy, and learning disabilities.
- Goals: Improve fine and gross motor skills, sensory processing, cognitive abilities, and social interaction.
- Interventions: Play activities, sensory integration, handwriting practice, and adaptive equipment.
Geriatric OT:
- Focus: Assists the elderly with daily tasks to maintain independence and quality of life.
- Goals: Enhance mobility, prevent falls, improve cognitive function, and promote social engagement.
- Interventions: Home modifications, adaptive equipment, cognitive training, and community integration.
Mental Health OT:
- Focus: Aids individuals with mental illnesses in developing routines and improving self-care.
- Goals: Foster independence, improve coping skills, enhance social interaction, and promote emotional well-being.
- Interventions: Life skills training, stress management, vocational rehabilitation, and group therapy.
Physical Rehabilitation OT:
- Focus: Helps individuals recovering from physical injuries, surgeries, or illnesses.
- Goals: Restore physical function, improve mobility, reduce pain, and enhance overall health.
- Interventions: Therapeutic exercises, manual therapy, adaptive equipment, and pain management techniques.
Neurological OT:
- Focus: Supports individuals with neurological conditions such as stroke, Parkinson’s disease, and multiple sclerosis.
- Goals: Improve motor function, cognitive abilities, and daily living skills.
- Interventions: Neurodevelopmental techniques, cognitive rehabilitation, and adaptive strategies for daily activities.
Core Areas of OT
Self-Care Skills:
- Bathing: Assisting patients in maintaining personal hygiene and independence in bathing.
- Dressing: Helping patients develop the skills to dress themselves appropriately.
- Eating: Enhancing patients’ ability to feed themselves and maintain proper nutrition.
- Toileting: Supporting patients in managing their toileting needs independently.
Social Skills:
- Communication: Improving verbal and non-verbal communication skills.
- Cooperation: Fostering the ability to work with others and participate in group activities.
- Appropriate Interactions: Teaching patients how to interact socially in a manner that is respectful and effective.
Academic and Vocational Skills:
- Task Completion: Helping patients develop the ability to complete tasks efficiently and effectively.
- Productivity: Enhancing patients’ capacity to be productive in academic or work settings.
- Goal Setting: Assisting patients in setting and achieving realistic goals related to their academic or vocational pursuits.
Motor Skills:
- Fine Motor Skills: Improving hand-eye coordination, dexterity, and precision in tasks requiring fine movements.
- Gross Motor Skills: Enhancing large muscle movements, balance, and coordination.
Cognitive Skills:
- Problem-Solving: Developing the ability to identify problems, generate solutions, and make decisions.
- Memory: Enhancing short-term and long-term memory through various cognitive exercises.
- Attention: Improving the ability to focus and sustain attention on tasks.
Sensory Integration:
- Sensory Processing: Helping individuals process and respond to sensory information from the environment.
- Sensory Modulation: Teaching strategies to manage sensory input and reduce sensory overload.
Role of Nurses in OT
Assessment and Planning:
- Conduct Assessments: Evaluate the patient’s physical, cognitive, and emotional needs to determine the appropriate OT interventions.
- Plan Activities: Develop a personalized OT plan that addresses the patient’s specific goals and challenges.
Execution and Documentation:
- Oversee Activities: Supervise the implementation of OT activities to ensure they are performed safely and effectively.
- Document Progress: Record the patient’s progress, challenges, and outcomes to adjust the OT plan as needed.
Support and Motivation:
- Provide Emotional Support: Offer encouragement and emotional support to help patients stay motivated and engaged in their OT program.
- Motivate Patients: Use positive reinforcement and goal-setting techniques to motivate patients to achieve their OT objectives.
Collaboration:
- Interdisciplinary Teamwork: Work closely with occupational therapists, physicians, and other healthcare professionals to provide comprehensive care.
- Family Involvement: Educate and involve family members in the OT process to support the patient’s progress and independence.
Education:
- Patient Education: Teach patients about their condition, the benefits of OT, and strategies to manage their daily activities.
- Caregiver Training: Provide training and resources for caregivers to support the patient’s OT goals at home.
Advocacy:
- Patient Advocacy: Advocate for the patient’s needs and rights within the healthcare system.
- Community Resources: Connect patients with community resources and support services to enhance their quality of life.
Recreational Therapy
Recreational therapy (RT) uses leisure activities to improve physical, emotional, and social well-being. RT is an integral part of psychiatric care, helping patients build coping skills, reduce stress, and enhance quality of life.
Goals of Recreational Therapy
- Promote Relaxation: Activities that help reduce anxiety and promote a sense of calm.
- Enhance Social Skills: Group activities that encourage interaction and teamwork.
- Improve Physical Health: Incorporate exercise to boost mood and energy levels.
- Build Coping Mechanisms: Teach healthy ways to manage stress and emotions.
- Increase Self-Esteem: Provide opportunities for achievement and positive feedback.
Techniques in Recreational Therapy
- Leisure Education: Teaching patients how to identify and engage in enjoyable activities.
- Group Games: Activities like board games or sports to promote social interaction.
- Creative Expression: Art, music, or dance therapy to express emotions.
- Outdoor Activities: Nature walks or gardening to connect with the environment.
- Relaxation Techniques: Yoga, meditation, or guided imagery to reduce stress.
Benefits of Recreational Therapy
- Reduced Stress: Engaging in enjoyable activities lowers cortisol levels and promotes relaxation.
- Improved Mood: Physical activity releases endorphins, improving overall mood.
- Enhanced Social Connections: Group activities foster relationships and support networks.
- Increased Motivation: Success in recreational activities can motivate patients in other areas of recovery.
- Better Quality of Life: RT helps patients find joy and purpose in daily life.
Psychological Therapy
Psychological therapies, also known as psychotherapies, are non-pharmacological treatments that focus on changing thought patterns, behaviors, and emotional responses. They are essential in psychiatry for long-term management and recovery.
Types of Psychological Therapies
- Cognitive Behavioral Therapy (CBT).
- Description: CBT focuses on identifying and changing negative thought patterns and behaviors.
- Techniques: Cognitive restructuring, behavioral activation, and exposure therapy.
- Applications: Effective for depression, anxiety, PTSD, and eating disorders.
- Dialectical Behavior Therapy (DBT).
- Description: A form of CBT that emphasizes mindfulness, emotion regulation, and interpersonal effectiveness.
- Techniques: Skills training in mindfulness, distress tolerance, emotion regulation, and interpersonal effectiveness.
- Applications: Particularly useful for borderline personality disorder and self-harm behaviors.
- Interpersonal Therapy (IPT).
- Description: Focuses on improving interpersonal relationships and social functioning.
- Techniques: Exploring role transitions, grief, interpersonal disputes, and deficits.
- Applications: Effective for depression, especially when related to life changes or relationships.
- Psychoanalytic Therapy.
- Description: Explores unconscious thoughts and early life experiences to understand current behaviors.
- Techniques: Free association, dream analysis, and transference interpretation.
- Applications: Useful for personality disorders and long-term emotional issues.
Psychotherapy
Psychotherapy is a collaborative process between a therapist and patient aimed at improving mental health through talk therapy.
Types of Psychotherapy
- Individual Therapy.
- Description: One-on-one sessions focusing on personal issues and goals.
- Benefits: Allows for deep exploration of individual thoughts and feelings.
- Group Therapy.
- Description: Sessions with multiple patients sharing similar issues.
- Benefits: Provides support, reduces isolation, and allows learning from others’ experiences.
- Family Therapy.
- Description: Involves family members to improve communication and resolve conflicts.
Benefits:
- Improves family dynamics and communication patterns.
- Addresses systemic issues contributing to individual mental health problems.
- Enhances support systems and reduces relapse risk through family involvement.
Goals of Psychotherapy
- Symptom Reduction: Alleviate distress from symptoms like anxiety, depression, or psychosis.
- Insight Development: Help patients understand unconscious conflicts, thought patterns, or behavioral triggers.
- Behavioral Change: Promote adaptive coping strategies and healthier interpersonal interactions.
- Emotional Regulation: Teach skills to manage intense emotions and prevent impulsive actions.
- Relapse Prevention: Build resilience and long-term strategies to maintain mental stability.
Techniques in Psychotherapy
- Active Listening: Therapist provides empathetic, non-judgmental reflection to validate patient experiences.
- Cognitive Restructuring: Identify and challenge distorted thoughts (e.g., “I am worthless” → “I have value despite setbacks”).
- Role-Playing: Practice social interactions or conflict resolution in a safe environment.
- Homework Assignments: Real-world application of skills learned in sessions (e.g., journaling, exposure tasks).
- Transference Analysis: Explore feelings projected onto the therapist that originate from past relationships.
Physical Treatments in Psychiatry (Summary)
| Category | Examples | Primary Use |
|---|---|---|
| Psychopharmacology | Antipsychotics, Antidepressants, Mood Stabilizers, Anxiolytics, Anticonvulsants | Symptom control, prevention of relapse |
| Electroconvulsive Therapy (ECT) | Bilateral/Unilateral electrode placement under anesthesia | Severe depression, catatonia, treatment-resistant psychosis |
| Occupational Therapy | ADL training, vocational rehab, cognitive remediation | Functional independence, social reintegration |
| Recreational Therapy | Art, music, sports, leisure education | Stress reduction, mood enhancement, socialization |
Key Antipsychotics (Quick Reference)
| Drug | Class | Key Indications | Common Side Effects | Monitoring |
|---|---|---|---|---|
| Chlorpromazine | Typical (Phenothiazine) | Acute psychosis, agitation | Sedation, hypotension, anticholinergic effects | BP, ECG |
| Haloperidol | Typical (Butyrophenone) | Acute schizophrenia, delirium | High EPS, akathisia, NMS risk | EPS scale, ECG (QTc) |
| Risperidone | Atypical | Positive & negative symptoms | Hyperprolactinemia, weight gain | Prolactin, weight |
| Olanzapine | Atypical | Schizophrenia, bipolar mania | Significant weight gain, metabolic syndrome | Glucose, lipids |
| Clozapine | Atypical | Treatment-resistant schizophrenia | Agranulocytosis, seizures, sialorrhea | Weekly CBC (first 6 months) |
Electroconvulsive Therapy (ECT) – At a Glance
| Aspect | Details |
|---|---|
| Indications | Severe MDD with psychosis/suicidality, catatonia, mania, treatment-resistant schizophrenia |
| Contraindications | Raised ICP, recent MI, uncontrolled hypertension |
| Procedure | General anesthesia + muscle relaxant → Brief pulse electrical stimulus → Seizure (30–60 sec) |
| Efficacy | 70–90% response in severe depression |
| Side Effects | Retrograde amnesia (usually resolves), headache, confusion |
| Nursing Role | Pre: NPO, consent, remove dentures During: Monitor VS, EEG Post: Reorient, monitor cognition |
Non-Pharmacological Adjuncts
Occupational Therapy Goals
- Restore ADL independence (bathing, dressing, cooking)
- Improve cognitive function (memory, executive skills)
- Enhance vocational readiness
Recreational Therapy Activities
- Structured: Board games, team sports
- Expressive: Art, music, dance
- Nature-based: Gardening, walking groups
Integration of Treatment Modalities
| Patient Presentation | Recommended Combination |
|---|---|
| Acute psychotic episode | Antipsychotic (e.g., haloperidol IM) + benzodiazepine (if agitated) + safety monitoring |
| Chronic schizophrenia with negative symptoms | Atypical antipsychotic (e.g., olanzapine) + OT + group therapy |
| Treatment-resistant depression with suicidality | ECT + SSRI/SNRI + CBT |
| Bipolar mania | Mood stabilizer (lithium/valproate) + antipsychotic + family therapy |
Final Note: Physical treatments (especially antipsychotics and ECT) are cornerstone interventions in acute psychiatric emergencies and severe illness. Long-term management requires multimodal integration of psychopharmacology, psychotherapy, and rehabilitative therapies to achieve symptom control, functional recovery, and quality of life.
Always titrate medications slowly, monitor for side effects, and involve multidisciplinary teams.
Join Our WhatsApp Groups!
Are you a nursing or midwifery student looking for a space to connect, ask questions, share notes, and learn from peers?
Join our WhatsApp discussion groups today!
Join NowWe are a supportive platform dedicated to empowering student nurses and midwives through quality educational resources, career guidance, and a vibrant community. Join us to connect, learn, and grow in your healthcare journey
Quick Links
Our Courses
Legal / Policies
Get in Touch
(+256) 790 036 252
(+256) 748 324 644
Info@nursesonlinediscussion.com
Kampala ,Uganda
© 2026 Nurses online discussion. All Rights Reserved